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Lipid ionizable lipids sirna amine cyclodextrin composition composed cationic therapeutics nanoparticles cylindrical hexagonal hydrophobic linker endosomal phase tails dlin anionic38 illustration of the lipid phase separation model for low temperature General phase diagram of phase coexistence in ternary lipid bilayers ofFigure 2 from order of lipid phases in model and plasma membranes.